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The USS Archer (NCC-44278) was a Federation Excelsior-class starship operated by Starfleet in the 24th century. (Star Trek Encyclopedia)

In 2367, the Archer was one of eleven Federation starships that were on standby to assist the USS Enterprise-D in evacuating the survivors of the Lolligan species to Starbases 213 and 85 so that Starfleet Medical can place them in hibernation chambers while they developed a cure for an unknown plague. The Archer was stood down when Doctor Beverly Crusher and her team developed a treatment. (TNG: "Terra Incognita, Issue 5")

In 2379, the Archer was assigned to Starfleet Battle Group Omega. Around stardate 56844, the the battle group was ordered to rendezvous with the USS Enterprise-E in sector 1045. The Enterprise-E was being pursued by the Reman warbird Scimitar, commanded by Praetor Shinzon. However, the Enterprise-E was forced to face the Scimitar alone after she was ambushed in the Bassen Rift. (Star Trek Nemesis)

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