Star Trek: Vanguard is a novel series released by Pocket Books from 2005 - 2012. It takes place on a 23rd Century space station known as Starbase 47 aka Vanguard, located in a barely explored region of space known as the Taurus Reach. One of the main missions of the crew of Vanguard is to investigate the Meta Genome, a mysterious, complex genome that is discovered all over the Taurus Reach. The Klingons, Romulans, Tholians, and an ancient mysterious race native to the Taurus Reach all become involved as the series progresses.
The series is set at the same time as The Original Series, and some of it's events add new context to certain episodes.